I IONIS PHARMACEUTICALS INC.
$74.79
| Market Cap | $12.35B |
| P/E Ratio | — |
| Forward P/E | -120.22 |
| Dividend Yield | — |
| Beta | 0.40 |
| 52W Range | $25.51 - $86.50 |
| # Hedge Funds | 1 |
| Sector | Healthcare |
| Industry | Biotechnology |
Hedge Fund Ownership
| Investor 1 | % of Portfolio Weight of this stock in the investor's portfolio | Value Total dollar value of the position | Shares Number of shares held | Activity Portfolio change type: New, Increased, Decreased, or Sold |
|---|---|---|---|---|
| Tweedy Browne Co. Tweedy Browne Co LLC | 15.74% | $195.00M | 2,464,930 | Reduce 15.04% |
Insider Trading
| Insider Name of the company insider who made the trade 132 | Type Purchase (buy) or Sale (sell) | Shares Number of shares traded | Price Price per share at time of transaction | Value Total dollar value of the transaction | Trade Date Date the transaction was executed | Filing Date Date the SEC filing was submitted |
|---|---|---|---|---|---|---|
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 6,193 | $74.05 | $458.61K | 02 Apr 2026 | 02 Apr 2026 |
| KLEIN JOSEPH III | Sale | 2,216 | $75.95 | $168.31K | 01 Apr 2026 | 01 Apr 2026 |
| KLEIN JOSEPH III | Sale | 20,105 | $75.50 | $1.52M | 01 Apr 2026 | 01 Apr 2026 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Sale | 5,812 | $70.97 | $412.49K | 19 Mar 2026 | 19 Mar 2026 |
| HOUGEN ELIZABETH LEVP, Finance & CFO | Sale | 10,172 | $73.21 | $744.66K | 17 Mar 2026 | 16 Mar 2026 |
| HOUGEN ELIZABETH LEVP, Finance & CFO | Sale | 9,440 | $72.77 | $686.90K | 16 Mar 2026 | 16 Mar 2026 |
| HOUGEN ELIZABETH LEVP, Finance & CFO | Sale | 205,608 | $72.38 | $14.88M | 16 Mar 2026 | 16 Mar 2026 |
| Monia Brett PChief Executive Officer | Sale | 17,591 | $76.34 | $1.34M | 10 Mar 2026 | 09 Mar 2026 |
| Monia Brett PChief Executive Officer | Sale | 16,512 | $75.47 | $1.25M | 10 Mar 2026 | 09 Mar 2026 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Sale | 16,086 | $76.30 | $1.23M | 10 Mar 2026 | 10 Mar 2026 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Sale | 21,191 | $75.50 | $1.60M | 10 Mar 2026 | 10 Mar 2026 |
| Monia Brett PChief Executive Officer | Sale | 1,684 | $75.58 | $127.28K | 09 Mar 2026 | 09 Mar 2026 |
| Monia Brett PChief Executive Officer | Sale | 117,604 | $75.26 | $8.85M | 09 Mar 2026 | 09 Mar 2026 |
| Monia Brett PChief Executive Officer | Sale | 7,382 | $74.11 | $547.09K | 09 Mar 2026 | 09 Mar 2026 |
| O'NEIL PATRICK R.EVP CLO & General Counsel | Sale | 10,148 | $75.25 | $763.66K | 09 Mar 2026 | 09 Mar 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 201 | $80.00 | $16.08K | 04 Mar 2026 | 05 Mar 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 238 | $80.00 | $19.04K | 04 Mar 2026 | 05 Mar 2026 |
| LOSCALZO JOSEPH | Sale | 200 | $80.00 | $16.00K | 04 Mar 2026 | 05 Mar 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 36 | $81.01 | $2.92K | 03 Mar 2026 | 05 Mar 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 4,096 | $79.36 | $325.06K | 03 Mar 2026 | 05 Mar 2026 |
| Diaz Allene M. | Sale | 14,608 | $79.88 | $1.17M | 03 Mar 2026 | 05 Mar 2026 |
| Diaz Allene M. | Sale | 39,265 | $79.11 | $3.11M | 03 Mar 2026 | 05 Mar 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 755 | $80.84 | $61.03K | 03 Mar 2026 | 05 Mar 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 802 | $80.76 | $64.77K | 03 Mar 2026 | 05 Mar 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 12,687 | $79.88 | $1.01M | 03 Mar 2026 | 05 Mar 2026 |
| KLEIN JOSEPH III | Sale | 1,012 | $80.82 | $81.79K | 03 Mar 2026 | 05 Mar 2026 |
| KLEIN JOSEPH III | Sale | 6,794 | $80.00 | $543.49K | 03 Mar 2026 | 05 Mar 2026 |
| KLEIN JOSEPH III | Sale | 13,526 | $79.17 | $1.07M | 03 Mar 2026 | 05 Mar 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 2,088 | $80.41 | $167.89K | 03 Mar 2026 | 05 Mar 2026 |
| LOSCALZO JOSEPH | Sale | 832 | $80.33 | $66.83K | 03 Mar 2026 | 05 Mar 2026 |
| Diaz Allene M. | Sale | 1,005 | $80.80 | $81.20K | 03 Mar 2026 | 05 Mar 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 5,030 | $80.00 | $402.39K | 03 Mar 2026 | 05 Mar 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 14,321 | $79.12 | $1.13M | 03 Mar 2026 | 05 Mar 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 71,600 | $79.10 | $5.66M | 03 Mar 2026 | 05 Mar 2026 |
| Swayze EricEVP Research | Sale | 6,207 | $82.07 | $509.40K | 13 Feb 2026 | 13 Feb 2026 |
| Swayze EricEVP Research | Sale | 9,435 | $81.56 | $769.51K | 13 Feb 2026 | 13 Feb 2026 |
| PARSHALL B LYNNE | Sale | 5,000 | $82.72 | $413.59K | 11 Feb 2026 | 13 Feb 2026 |
| Monia Brett PChief Executive Officer | Sale | 29,430 | $85.79 | $2.52M | 06 Feb 2026 | 10 Feb 2026 |
| Brett P MoniaChief Executive Officer | Sale | 29,430 | $85.79 | $2.52M | 06 Feb 2026 | 10 Feb 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 20,000 | $82.60 | $1.65M | 02 Feb 2026 | 04 Feb 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 16,463 | $83.03 | $1.37M | 02 Feb 2026 | 04 Feb 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 48,626 | $83.03 | $4.04M | 02 Feb 2026 | 04 Feb 2026 |
| Swayze EricEVP Research | Sale | 6,179 | $82.93 | $512.45K | 30 Jan 2026 | 02 Feb 2026 |
| HOUGEN ELIZABETH LEVP, Finance & CFO | Sale | 6,988 | $83.24 | $581.70K | 30 Jan 2026 | 02 Feb 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 5,296 | $82.96 | $439.36K | 30 Jan 2026 | 02 Feb 2026 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Sale | 6,179 | $83.45 | $515.63K | 30 Jan 2026 | 02 Feb 2026 |
| Birchler BrianEVP, Corp and Development Ops | Sale | 6,179 | $83.03 | $513.05K | 30 Jan 2026 | 02 Feb 2026 |
| Monia Brett PChief Executive Officer | Sale | 62,970 | $82.72 | $5.21M | 30 Jan 2026 | 02 Feb 2026 |
| Eugene SchneiderEVP, Chf Clinical Develop Ofcr | Sale | 6,179 | $83.45 | $515.63K | 30 Jan 2026 | 02 Feb 2026 |
| O'NEIL PATRICK R.EVP CLO & General Counsel | Sale | 6,179 | $83.53 | $516.15K | 30 Jan 2026 | 02 Feb 2026 |
| Brett P MoniaChief Executive Officer | Sale | 62,970 | $82.72 | $5.21M | 30 Jan 2026 | 02 Feb 2026 |
| Eric SwayzeEVP Research | Sale | 6,179 | $82.93 | $512.45K | 30 Jan 2026 | 02 Feb 2026 |
| Joseph BaroldiEVP, Chief Business Officer | Sale | 5,296 | $82.96 | $439.36K | 30 Jan 2026 | 02 Feb 2026 |
| Brian BirchlerEVP, Corp and Development Ops | Sale | 6,179 | $83.03 | $513.05K | 30 Jan 2026 | 02 Feb 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 5,885 | $82.95 | $488.14K | 30 Jan 2026 | 02 Feb 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 3,977 | $81.34 | $323.49K | 22 Jan 2026 | 23 Jan 2026 |
| BENNETT C FRANKEVP, Chief Scientific Officer | Sale | 8,977 | $75.15 | $674.62K | 16 Jan 2026 | 20 Jan 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 8,353 | $75.95 | $634.41K | 16 Jan 2026 | 20 Jan 2026 |
| HOUGEN ELIZABETH LEVP, Finance & CFO | Sale | 12,922 | $75.22 | $971.99K | 16 Jan 2026 | 20 Jan 2026 |
| Swayze EricEVP Research | Sale | 9,884 | $75.34 | $744.66K | 16 Jan 2026 | 20 Jan 2026 |
| O'NEIL PATRICK R.EVP CLO & General Counsel | Sale | 9,191 | $75.84 | $697.05K | 16 Jan 2026 | 20 Jan 2026 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Sale | 9,302 | $75.59 | $703.14K | 16 Jan 2026 | 20 Jan 2026 |
| Monia Brett PChief Executive Officer | Sale | 44,034 | $74.82 | $3.29M | 16 Jan 2026 | 20 Jan 2026 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Sale | 1,823 | $75.96 | $138.48K | 16 Jan 2026 | 20 Jan 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 1,149 | $75.78 | $87.07K | 16 Jan 2026 | 20 Jan 2026 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 6,907 | $75.75 | $523.21K | 16 Jan 2026 | 20 Jan 2026 |
| Birchler BrianEVP, Corp and Development Ops | Sale | 8,480 | $75.11 | $636.93K | 16 Jan 2026 | 20 Jan 2026 |
| Swayze EricEVP Research | Sale | 49 | $75.97 | $3.72K | 16 Jan 2026 | 20 Jan 2026 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Sale | 4,141 | $75.66 | $313.31K | 16 Jan 2026 | 20 Jan 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 9,264 | $84.62 | $783.92K | 07 Jan 2026 | 09 Jan 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 3,829 | $84.62 | $324.01K | 07 Jan 2026 | 09 Jan 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 2,101 | $85.36 | $179.34K | 07 Jan 2026 | 09 Jan 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 25,545 | $85.36 | $2.18M | 07 Jan 2026 | 09 Jan 2026 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 3,460 | $84.62 | $292.79K | 07 Jan 2026 | 09 Jan 2026 |
| Swayze EricEVP Research | Sale | 18,338 | $79.27 | $1.45M | 02 Jan 2026 | 06 Jan 2026 |
| Swayze EricEVP Research | Sale | 5,125 | $78.57 | $402.67K | 02 Jan 2026 | 06 Jan 2026 |
| Eric SwayzeEVP Research | Sale | 18,338 | $79.27 | $1.45M | 02 Jan 2026 | 06 Jan 2026 |
| Eric SwayzeEVP Research | Sale | 5,125 | $78.57 | $402.67K | 02 Jan 2026 | 06 Jan 2026 |
| WENDER JOSEPH H | Sale | 7,429 | $81.23 | $603.49K | 01 Dec 2025 | 03 Dec 2025 |
| WENDER JOSEPH H | Sale | 20,571 | $80.67 | $1.66M | 01 Dec 2025 | 03 Dec 2025 |
| Joseph H WenderDirector | Sale | 7,429 | $81.23 | $603.49K | 01 Dec 2025 | 03 Dec 2025 |
| Joseph H WenderDirector | Sale | 20,571 | $80.67 | $1.66M | 01 Dec 2025 | 03 Dec 2025 |
| KLEIN JOSEPH III | Sale | 4,000 | $80.00 | $320.00K | 25 Nov 2025 | 28 Nov 2025 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 16,777 | $80.91 | $1.36M | 25 Nov 2025 | 28 Nov 2025 |
| Joseph Klein IIIDirector | Sale | 4,000 | $80.00 | $320.00K | 25 Nov 2025 | 28 Nov 2025 |
| Shannon L. DeversEVP, Chief Human Resources Ofc | Sale | 16,777 | $80.91 | $1.36M | 25 Nov 2025 | 28 Nov 2025 |
| HERMAN JOAN E | Sale | 32,000 | $72.13 | $2.31M | 19 Nov 2025 | 20 Nov 2025 |
| HERMAN JOAN E | Sale | 12,000 | $72.13 | $865.59K | 19 Nov 2025 | 20 Nov 2025 |
| Joan E HermanDirector | Sale | 12,000 | $72.13 | $865.59K | 19 Nov 2025 | 20 Nov 2025 |
| Joan E HermanDirector | Sale | 32,000 | $72.13 | $2.31M | 19 Nov 2025 | 20 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 18,300 | $75.42 | $1.38M | 06 Nov 2025 | 07 Nov 2025 |
| Birchler BrianEVP, Corp and Development Ops | Sale | 8,000 | $76.17 | $609.38K | 06 Nov 2025 | 07 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 14,738 | $76.10 | $1.12M | 06 Nov 2025 | 07 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 800 | $75.01 | $60.01K | 05 Nov 2025 | 07 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 801 | $75.01 | $60.08K | 05 Nov 2025 | 07 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 775 | $75.05 | $58.17K | 03 Nov 2025 | 03 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 905 | $75.05 | $67.92K | 03 Nov 2025 | 03 Nov 2025 |
| Richard S GearyEVP, Chief Development Officer | Sale | 905 | $75.05 | $67.92K | 03 Nov 2025 | 03 Nov 2025 |
| Richard S GearyEVP, Chief Development Officer | Sale | 775 | $75.05 | $58.17K | 03 Nov 2025 | 03 Nov 2025 |
| WENDER JOSEPH H | Sale | 11,200 | $75.16 | $841.78K | 31 Oct 2025 | 03 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 20,000 | $75.11 | $1.50M | 31 Oct 2025 | 03 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 34,664 | $75.11 | $2.60M | 31 Oct 2025 | 03 Nov 2025 |
| Geary Richard SEVP, Chief Development Officer | Sale | 34,585 | $75.11 | $2.60M | 31 Oct 2025 | 03 Nov 2025 |
| LOSCALZO JOSEPH | Sale | 16,000 | $75.10 | $1.20M | 31 Oct 2025 | 03 Nov 2025 |
| Joseph H WenderDirector | Sale | 11,200 | $75.16 | $841.78K | 31 Oct 2025 | 03 Nov 2025 |
| Joseph LoscalzoDirector | Sale | 16,000 | $75.10 | $1.20M | 31 Oct 2025 | 03 Nov 2025 |
| Richard S GearyEVP, Chief Development Officer | Sale | 34,664 | $75.11 | $2.60M | 31 Oct 2025 | 03 Nov 2025 |
| Richard S GearyEVP, Chief Development Officer | Sale | 20,000 | $75.11 | $1.50M | 31 Oct 2025 | 03 Nov 2025 |
| Richard S GearyEVP, Chief Development Officer | Sale | 34,585 | $75.11 | $2.60M | 31 Oct 2025 | 03 Nov 2025 |
| WENDER JOSEPH H | Sale | 5,975 | $73.85 | $441.25K | 30 Oct 2025 | 03 Nov 2025 |
| WENDER JOSEPH H | Sale | 8,341 | $73.16 | $610.23K | 30 Oct 2025 | 03 Nov 2025 |
| WENDER JOSEPH H | Sale | 2,484 | $72.19 | $179.32K | 30 Oct 2025 | 03 Nov 2025 |
| Joseph H WenderDirector | Sale | 8,341 | $73.16 | $610.23K | 30 Oct 2025 | 03 Nov 2025 |
| Joseph H WenderDirector | Sale | 5,975 | $73.85 | $441.25K | 30 Oct 2025 | 03 Nov 2025 |
| Joseph H WenderDirector | Sale | 2,484 | $72.19 | $179.32K | 30 Oct 2025 | 03 Nov 2025 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 1,263 | $73.62 | $92.98K | 16 Oct 2025 | 16 Oct 2025 |
| Swayze EricEVP Research | Sale | 53 | $73.62 | $3.90K | 16 Oct 2025 | 16 Oct 2025 |
| Eric SwayzeEVP Research | Sale | 53 | $73.62 | $3.90K | 16 Oct 2025 | 16 Oct 2025 |
| Shannon L. DeversEVP, Chief Human Resources Ofc | Sale | 1,263 | $73.62 | $92.98K | 16 Oct 2025 | 16 Oct 2025 |
| PARSHALL B LYNNE | Sale | 5,000 | $71.74 | $358.72K | 15 Oct 2025 | 16 Oct 2025 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sale | 6,000 | $72.94 | $437.65K | 15 Oct 2025 | 16 Oct 2025 |
| Birchler BrianEVP, Corp and Development Ops | Sale | 12,425 | $72.23 | $897.40K | 15 Oct 2025 | 16 Oct 2025 |
| Lynne B ParshallDirector | Sale | 5,000 | $71.74 | $358.72K | 15 Oct 2025 | 16 Oct 2025 |
| Brian BirchlerEVP, Corp and Development Ops | Sale | 12,425 | $72.23 | $897.40K | 15 Oct 2025 | 16 Oct 2025 |
| Shannon L. DeversEVP, Chief Human Resources Ofc | Sale | 6,000 | $72.94 | $437.65K | 15 Oct 2025 | 16 Oct 2025 |
| Birchler BrianEVP, Corp and Development Ops | Sale | 11,475 | $72.03 | $826.59K | 14 Oct 2025 | 16 Oct 2025 |
| Brian BirchlerEVP, Corp and Development Ops | Sale | 11,475 | $72.03 | $826.59K | 14 Oct 2025 | 16 Oct 2025 |
| Swayze EricEVP Research | Sale | 6,849 | $69.02 | $472.72K | 06 Oct 2025 | 08 Oct 2025 |
| O'NEIL PATRICK R.EVP CLO & General Counsel | Sale | 3,241 | $69.27 | $224.49K | 06 Oct 2025 | 08 Oct 2025 |
| O'NEIL PATRICK R.EVP CLO & General Counsel | Sale | 10,200 | $69.89 | $712.85K | 06 Oct 2025 | 08 Oct 2025 |
| Baroldi JosephEVP, Chief Business Officer | Sale | 1,625 | $69.37 | $112.73K | 06 Oct 2025 | 08 Oct 2025 |
| Monia Brett PChief Executive Officer | Sale | 437 | $69.26 | $30.27K | 06 Oct 2025 | 08 Oct 2025 |
Frequently Asked Questions
What is IONS stock price today?
IONIS PHARMACEUTICALS INC. (IONS) is currently trading at $74.79. The stock has a 52-week range of $25.51 to $86.50 and a market capitalization of $12.35B.
Is IONS a good stock to buy in 2026?
IONIS PHARMACEUTICALS INC. has a P/E ratio of N/A (forward P/E: N/A), a dividend yield of none, and 1-year performance of +162.2%. 1 hedge funds hold this stock. Review the fundamentals and ownership data above to make an informed decision.
Are insiders buying or selling IONS stock?
There have been 132 insider transactions for IONS in recent months. Insider buys can signal management confidence, while sales may reflect diversification or personal financial planning. Check the Insider Trading section above for details.
How has IONS stock performed over the past year?
IONIS PHARMACEUTICALS INC. (IONS) has returned +162.2% over the past 12 months. The stock traded between $25.51 and $86.50 during this period, and is currently at $74.79.
Which hedge funds own IONS (IONIS PHARMACEUTICALS INC.)?
1 tracked hedge funds currently hold IONS in their portfolios as of the latest 13F filings. See the ownership table above for the complete list.
What is IONS's market cap and valuation?
IONIS PHARMACEUTICALS INC. (IONS) has a market capitalization of $12.35B. The trailing P/E ratio is N/A and forward P/E is N/A. The stock is classified in the Healthcare sector.
What is IONS's revenue and profitability?
IONIS PHARMACEUTICALS INC. reported revenue of $943.71M with net income of N/A and a profit margin of N/A. The stock has a beta of 0.40.
What sector is IONS in and who are its biggest institutional holders?
IONIS PHARMACEUTICALS INC. (IONS) operates in the Healthcare sector. It is held by 1 tracked hedge funds. See the ownership table above for the complete list.